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Serum-Free Cell Culture Media (No BSE that is, Mad Cow Disease)
Est. Market Size - $2 B
PRODUCT CONSTITUENT
Market Needs?
The growth medium for cells grown in culture is routinely supplemented with animal and/or human serum to optimize and enhance cell viability. The constituents of serum include water, amino acids, glucose, albumins, immunoglobulins, and one or more bioactive agents. Potential bioactive agents present in serum include agents that induce proliferation, agents that accelerate phenotypic expression, agents that induce differentiation, agents that inhibit proliferation, agents that inhibit phenotypic expression, and agents that inhibit differentiation.
Unfortunately, the identity(ies), concentration(s), and potential combinations of specific bioactive agents contained in different lots of serum is/are unknown. One or more of these unknown agents in serum have shown a negative impact on the isolation, cultivation, cryopreservation, and purification of lineage-uncommitted stem cells. To circumvent the problems inherent with the use of serum, serum-free defined reagents were devised for the isolation, cultivation, cryopreservation, and purification of lineage-uncommitted stem cells.
Market Trends in Mammalian Cell Culture
Media Demand - Expected to continue to growing at least 12-15% per year.
Sera Demand - Still Strong and shortages have resulted.
Serum-free media (SFM) - Progress continues to be made in developing SFM for increasingly diverse array of cell lines and types.
Other Media - Novel media for specialized cell cultures growing in scope.
Customization - Seen as a significant growth area.
Pricing - Pricing has been mixed: SFM pricing has strengthened over the last three years, but classical formulations have lagged.
Market Shares - Most firms have grown with the market. JRH appears to have gained some market share.
Competing Culture Systems - Commercial application of competing culture systems will continue to be of research interest.
New Products - New culture media products continue to be developed for an increasingly complex and diverse array of applications
Product approvals - Biopharmaceutical product approvals expected to be at the same slow pace.
New Technologies - New technologies supporting Biopharmaceutical product expected to grow modestly.
Market
Companies
There are seven significant suppliers of mammalian cell culture media: · Cambrex, · HyClone · Invitrogen · Irvine Scientific (Santa Anna, CA) · JRH Bioscience · Mediatech (Herndon, VA) · Sigma-Aldrich
HyClone, Invitrogen, JRH Bioscience, and Sigma-Aldrich represent well over 80% of US market
Mammalian Cell Culture media market has been struggling to meet the growing demand for cell culture media. There has been a 30% increase of use in China alone. In the USA the manufacturers want to triple their manufacturing capacity within the next four years.
Year Capacity 2002 500,000 liters 2006 1,500,000 liters
The demand for custom media has been reported to be a major source of this growth, especially for serum-free media.
Serum-Free market share
Year % Total market 2000 12-15% 2004 18-20%
Serum-free revenues were approximately $40M for 2003. Concerns over Mad Cow Disease (Bovine Spongiform Encephalitis) BSE - free sources are important even though public attention to the issue has waned. The FDA still considers BSE a risk.
Market Size – Est. $2 B
Cell culture media has a number of components within it to make it functional. Traditionally, researchers have purchased a base media and any required factors and additives separately. Market revenues have thus been collected separately.
Media Market
Year $ 2003 $180M 2004 $200
As stated above custom media is showing enormous growth at this time. Much of that customization is in fact the mixing of all necessary reagents and components so the researcher can simply open the bottle and pour. When these considerations are included the USA market for media, sera, and other needed reagents:
Year $ 2003 $915.6M 2008 $1.7B
There is an expected market growth rate of 13.1% per year. AAGR is likely to be much bigger. It is possible that a 5X increase in demand will be seen in the next 4 years.
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